Wydział Nauk o Zdrowiu (WNZ)

Stały URI dla tego zespołu

https://hdl.handle.net/20.500.13044/15

Przeglądaj

Przeglądanie Wydział Nauk o Zdrowiu (WNZ) według Autor "Augustynowicz-Kopeć, Ewa"
  • Rekord
    Analysis of resistance to antimycobacterial drugs among MTBC strains isolated from cattle in Poland as a threat to human health
    (Państwowa Szkoła Wyższa im. Papieża Jana Pawła II w Białej Podlaskiej, 2020-02-24) Weiner, Marcin ; Krajewska, Monika ; Zabost, Anna ; Augustynowicz-Kopeć, Ewa ; Szulowski, Krzysztof
    Background. Tuberculosis is a highly contagious disease affecting humans and animals. It is caused by mycobacteria that are part of the Mycobacterium tuberculosis complex (MTBC). The etiological agent causing bovine tuberculosis is mycobacteria bovis: Mycobacterium bovis and Mycobacterium caprae. According to the World Health Organization bovine tuberculosis is classified as direct zoonosis. Material and methods. T he s tudy m aterial c onsisted o f 1 29 M TBC s trains i solated f rom Polish cattle, which were microbiologically analyzed. The resistance phenotype was tested for first-line anti-tuberculosis drugs used in the treatment of tuberculosis in humans. The drugs included streptomycin, isoniazid, rifampicin, ethambutol, and pyrazinamide. The MTBC strains tested in this study were isolated from cattle tissue post mortem so that the determination of drug resistance could meet only the epidemiological criterion. Results. Polish strains of mycobacteria bovis have not acquired environmental resistance despite the huge dynamics of changes in the phenotype of mycobacterial tuberculosis resistance. Strains classified as M. bovis are characterized by natural resistance to PZA, which is typical of this species. Conclusions. Drug resistance imposes the use of additional drugs. Drugs that are less effective than the basic drugs, drugs causing side effects more frequently and drugs that are much more expensive.
  • Rekord
    Animal tuberculosis as a potential danger to men
    (Państwowa Szkoła Wyższa im. Papieża Jana Pawła II w Białej Podlaskiej, 2017-03-09) Krajewska, Monika ; Weiner, Marcin ; Augustynowicz-Kopeć, Ewa
    Tuberculosis (latin: tuberculosis) is an infectious disease which affects man and many species of animals. The aetiological factor of tuberculosis are bacillus which belong to the Mycobacterium tuberculosis complex (MTBC) while their host preferences, gene sequence and the level of drug resistance can differ. MTBC constitute a morphologically and biochemically homogeneous group of bacteria which mainly spreads through the aerogenic channel on small, dry particles of phlegm called droplet nuclei which are discharged while infected people or animals cough. Infection occurs after predisposed individual inhales into his or her lungs the bacilli, where they easily multiply in the soft lungs tissue and cause infection. The World Health Organization (WHO) classified bovine tuberculosis (bTB) as direct zoonosis, in which case the transmission of disease is possible without the indirect host’s involvement. Moreover, bTB is the best example of anthroponosis, when the disease is transferred from animal to men. The possibility of dividing the strains of animal bacillus into the two genres: M. bovis and M. caprae raises some significant legal concerns in Europe since in many of its countries, including among others Poland, caprae is not considered to be an etiological factor of bTB.