Książki/rozdziały (WNZ)

Stały URI dla tej kolekcji

Gastro-entero-pancreatic neuroendocrine tumors – a challenging group of rare neoplasms

(Państwowa Szkoła Wyższa im. Papieża Jana Pawła II w Białej Podlaskiej, 2013) Jeziorski, Krzysztof

Gastro-entero-pancreatic neuroendocrine tumors (GEP – NETs) are a heterogenous group of rare neoplsms which may develop from neuroendocrine cells located in different parts of the digestive system (the foregut, the midgut and the hindgut). The classifi cation is based on the mitotic rate and Ki67 labeling index. Therapy of GEP-NETs consists of different oncological methods such as: surgery, somatostatin analogs, interferon alpha, radioisotope therapy, chemotherapy and targeted therapy. Surgery remains the standard of care of neuroendocrine tumors of the digestive system. Resection or palliative debulking of liver metasatses may improve overall survival. Somatostatin analogs are not only used in controlling hormonal symptoms in patients with functional GEP-NETs but also as antiproliferative agents. Peptide receptor radionuclide therapy is a special form of therapy in which somatostatin analogs are conjugated with isotopes. Chemotherapy is of limited value in welldifferentiated GEP-NETs but is recommended in poorly differentiated GEP-NETs. Also, chemotherapy should be considered in individual patients when there is evidence of failure with other therapies. Targeted therapy is a new approach in the treatment of pancreatic neuroendocrine tumors.