2023, Volume 17, Issue 2

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https://hdl.handle.net/20.500.13044/1349

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Przeglądanie 2023, Volume 17, Issue 2 według Autor "Melnyk, Nataliia"
  • Rekord
    Determination of the epidemic threshold of an infectious disease
    (Akademia Bialska im. Jana Pawła II, 2023-06-28) Kashuba, Nikolay ; Melnyk, Nataliia
    Background. The purpose of this work was to develop a program algorithm for calculating and graphically constructing the level of the epidemic threshold of an infectious disease. Material and methods. To calculate the epidemic threshold of an infectious disease, a statistical method was applied. Microsoft Visual Basic was used (as a programming language and development environment) to write the program algorithm. MS Excel was used to enter the input data of the weekly incidence rate. Results. The algorithm of the program is quite easy to use; it consists of 12 consecutive steps with the entry of relevant data in each field of the window that appears. Thus, weekly information on the level of morbidity in a certain region for any period of the year (maximum 52 weeks) is entered into the program. After entering the information, the program displays a graph with the epidemic threshold value for each week. Due to this, it is possible to compare the level of the epidemic threshold in different periods of the year. Conclusions. The developed computer program makes it possible to determine the epidemic threshold of any infectious disease. It can be used to analyze and predict any infectious processes that are permanent, including COVID-19.
  • Rekord
    The effect of combined action of types of lead nanoparticles and stearates on indicators of the oxidative stress in the body of experimental animals
    (Akademia Bialska im. Jana Pawła II, 2023-06-28) Fedoriv, Olha ; Melnyk, Nataliia ; Kopach, Oleksandra
    Background. The aim of this work was to determine the effect of the combined action of nanoparticles of stearates and lead on the state of lipid peroxidation, antioxidant defense, and the level of circulating immune complexes in experimental rats. Material and methods. Experiments were conducted on four groups of white rats. The first (control) and second groups of animals consumed dechlorinated water from the city water supply. The third and fourth groups of animals consumed water, respectively, with the content of sodium stearate and potassium stearate in a dose of 1/250 LD50. After 40 days of drinking the indicated waters, the animals of the second, third, and fourth groups were orally injected with lead nanoparticles at a dose of 1/250 of the LD50. Results. The combined effect of sodium stearate and lead nanoparticles, potassium stearate, and lead nanoparticles had the character of additive action and potentiation according to most indicators of lipid peroxidation and antioxidant protection. According to the change of the circulating immune complexes indicator in the blood, it had the character of antagonistic action. Conclusions. The studies have shown that, in most indicators of lipid peroxidation and antioxidant system, the combined action of lead nanoparticles and stearates had the character of potentiation.