Health Problems of Civilization

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https://hdl.handle.net/20.500.13044/62

„Health Problems of Civilization" (ISSN 2353-6942) to czasopismo naukowe, które jest kontynuacją czasopisma „Human and Health", wydawanego w latach 2010-2013. Czasopismo publikowane jest wyłącznie w języku angielskim (streszczenie, tytuł i słowa kluczowe dodatkowo w języku polskim). Misją czasopisma jest promowanie wiedzy w zakresie różnych problemów zdrowotnych człowieka w świetle szybko postępujących zmian życia współczesnego, spowodowanych rozwojem cywilizacyjnym, industrializacją, urbanizacją oraz zmianami środowiska naturalnego, które wywierają często niekorzystny wpływ na zdrowie człowieka. Czasopismo publikuje artykuły w podziale na 3 działy tematyczne: Dział I. „Choroby i problemy wyróżnione przez WHO i FAO”, Dział II. „Aktywność fizyczna grup społecznych i zawodowych” oraz Dział III. „Inne”. Artykuły dotyczą różnych grup tematycznych, takich jak: biomedyczne aspekty zdrowia, współczesne choroby, aktywność fizyczna, zachowania zdrowotne. Czasopismo zastrzega sobie również prawo do skupienia się w wybranym numerze na jednym zakresie tematycznym, np. borelioza, gruźlica, aktywność fizyczna czy otyłość. Czasopismo „Health Problems of Civilization” daje możliwość publikacji artykułów dotyczących problematyki współczesnych zagrożeń, metod profilaktyki i edukacji prozdrowotnej oraz niekorzystnych zjawisk zdrowotnych.

Redaktor Naczelny: prof. dr hab. Marcin Weiner
Akademia Bialska im. Jana Pawła II, Polska

Zastępca Redaktora Naczelnego: dr hab. Małgorzata Tokarska-Rodak
Akademia Bialska im. Jana Pawła II, Polska

Sekretarz Redakcji: mgr Anna Maksymiuk
Akademia Bialska im. Jana Pawła II, Polska

Redaktor statystyczny: dr Agnieszka Kuś
Akademia Bialska im. Jana Pawła II, Polska

Redaktor językowy: dr Izabela Dąbrowska
Akademia Bialska im. Jana Pawła II, Polska

Redaktorzy tematyczni:

Biomedyczne aspekty zdrowia: dr Joanna Strzemecka
Akademia Bialska im. Jana Pawła II, Polska

Aktywność fizyczna: dr hab. Barbara Bergier
Akademia Bialska im. Jana Pawła II, Polska

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Features of pharmacotherapy of hepatic encephalopathy manifestations in liver cirrhosis

(Państwowa Szkoła Wyższa im. Papieża Jana Pawła II w Białej Podlaskiej, 2016-01-13) Meretskyi, Viktor ; Lobanets, Natalya

The aim of this work is to study the effect of drug mebikar on the clinical manifestations of hepatic encephalopathy in patients with liver cirrhosis. The study involved 34 patients with cirrhosis of different etiologies. The average age of the examined patients was (48.5±0.9) years, that prevailed patients of working age, indicating the medical and social significance of the problem of early diagnosis and adequate treatment of cirrhosis. One of the most frequent complications of cirrhosis is hepatic encephalopathy. In addition to conventional clinical and laboratory findings in patients with liver cirrhosis, severities of hepatic encephalopathy were determined according to West-Haven criteria before and after treatment. In patients with liver cirrhosis was established the presence of latent or clinically expressed hepatic encephalopathy. The treatment of the control group of patients consisted of the following drugs: essential phospholipids, mixture of sorbitol and major ions, arginine glutamate, furosemide, verospiron, lactulose, amoxicillin trihydrate and lansoprazole. In the complex treatment of the main group of patients medicine mebikar was administered additionally. Analysis of the clinical manifestations of hepatic encephalopathy showed a marked improvement in patients who received additional treatment with mebikar. Specifically, the incidences of mood changes as well as anxiety decreased in this group on average of 38% compared with those patients without an additional treatment with mebikar. Also, sleep disturbances in the main group was observed to be lower by 7.2% compared to those in the control group. Inclusion in the treatment of patients with liver cirrhosis, the drug mebikar – a daytime tranquilizer with anxiolytic properties reduces neurotic disorders, improves emotional state which may indicate a regression in the manifestations of hepatic encephalopathy thereby improving the quality of life of patientsand thus substantiating an expedient inclusion of mebikar an anxiolytic drug to the complex therapy of patients with liver cirrhosis.
Healthy Smile Prevention Project in Slovakia with students DH Klinik in Presov. Final report of study: cariosity of teeth among schoolchildren within two groups in Slovakia in 2002, 2005, 2007 and 2009

(Państwowa Szkoła Wyższa im. Papieża Jana Pawła II w Białej Podlaskiej, 2016-01-13) Kovaľová, Eva ; Eliašová, Anna ; Adamišin, Peter ; Koval, Alexander

Summary: In the thesis the authors present complex results of the epidemiological study of oral health of the 6 - 12-year old schoolchildren attending elementary schools in Prešov (Slovakia) who participated in the Healthy Smile Prevention Project. The participants of the Project were represented by the pre-school children and schoolchildren from the age of 4 years attending the pre-school facilities and elementary schools and the project was performed by the dental hygienist, dental disease prevention officer, and school dental care assistant under supervision of a dental practitioner. The oral health of the abovementioned project participants was compared with the oral health of the group of children not participating in the prevention project. The project was supported by the Swiss company GABA.
Is it possible to detect lung cancer by trained dogs?

(Państwowa Szkoła Wyższa im. Papieża Jana Pawła II w Białej Podlaskiej, 2016-01-13) Rudnicka, Joanna ; Walczak, Marta ; Jezierski, Tadeusz ; Buszewski, Bogusław

During the illness are released volatile organic compounds with specific smell which could have in diagnosis of diseases. The first aim of the study was qualitative and quantitative analysis of exhaled breath samples obtained from patients with lung cancer, healthy volunteers and people with other lung diseases by gas chromatography-mass spectrometry. This study showed that twenty compounds propane, ethanol, isobutane, butane, propanal, 1-propanol, 2-propanol, 2-methylfuran, 2-butanone, benzene, 2-pentanone, pentanal, hexanal, cyclohexanone, 4-heptanone, 2,4-dimethylheptane, 2,3,4-trimethylhexane, 2,3,5-trimethylhexane, 4-methyloctane, α-pinene separated two research groups of patients and healthy controls. The second goal was to evaluate the sensitivity and specificity of canine scent detection using 5 station scent lineup. Among lung cancer patients and complementary samples, overall sensitivity of canine scent detection was 85.54%, while specificity was 71.84%.
Tularemia – serious zoonotic disease

(Państwowa Szkoła Wyższa im. Papieża Jana Pawła II w Białej Podlaskiej, 2016-01-13) Weiner, Marcin ; Kubajka, Maria

Tularemia is an acute, infectious zoonotic disease caused by a smal. aerobic, intracellular, gram-negative bacillus Francisella tularensis. Tularemia was firstly described towards the end of nineteenth century in Japan, however, the name Francisella comes from Edward Francis, an American researcher who in 1911 detected this bacterium in squirrels in Tulare County, California. In Poland tularemia in humans was recognized for the first time in 1949. In the years 1949 to 2009, over 600 tularemia cases were recorded in Poland, with one fatality in 1983. Initial work on the use of F. tularensis as a biological weapon was carried out in the 30s of the twentieth century simultaneously in the United States, Soviet Union and Japan. The natural reservoirs of the micro-organism are rodents and lagomorphs, which can be a source of infection for other animals and humans. Human infection occurs through direct contact with sick animal. inhalation of dust contaminated with feces of sick animals and it takes place mainly in the farms involved in the animal production, to a lesser extent as a result of contaminated food and water.
The role of physical therapy in cancer treatment

(Państwowa Szkoła Wyższa im. Papieża Jana Pawła II w Białej Podlaskiej, 2016-01-13) Sidor, Mirosława ; Jeziorski, Krzysztof

Cancer is a very important problem in both medical and social respects. In recent years, there has been a shift in approach to oncological prevention, diagnostics and treatment. As a result, oncology has become an interdisciplinary field. Factors relevant for successful oncological treatment are: sequence, type and scope of intervention, including diagnosis of the cancer, assessment of its progression, systemic treatment, surgery, radiotherapy, supportive therapy and rehabilitation. Rehabilitation addresses the realm of psychology (psychooncology), as well as somatic and social issues. Physical therapy is a notion inseparably related to medical rehabilitation and it encompasses a range of treatments which are based on the body’s reactivity to stimuli. The purpose of this article is to present the specific character, the methods and the role of physical therapy in oncology, as an increasingly popular strategy in medicine, which helps to improve performance and physical function in cancer patients. Physical therapy is essential in primary and secondary cancer prevention and it greatly contributes to improving the quality of life of patients and helps them recover quicker. Four basic kinds of intervention in oncological rehabilitation include: preventive interventions, restorative interventions, supportive interventions and palliative interventions. The main principle in rehabilitating a patient with an advanced cancer is progressing steadily but gradually. The primary and essential form of rehabilitation for cancer patients is movement exercise i.e. kinesiotherapy. Integration and cooperation during group exercise are also among the strategies that therapists seek to employ while working to improve the condition of patients diagnosed with cancer. Kinesiotherapy prevents pulmonary and thromboembolic complications in cancer patients. One method of physical therapy applied in cancer treatment is lymphatic drainage (massage), which improves circulation of lymph. To sum up, physical therapy plays an increasingly important role in holistic care of cancer patients. It is indispensable and should become a standard approach, as a method of reducing the risk of complications, helping in faster recovery and limiting the economic and social costs of treatment.
Food quality control by hyphenated separation techniques

(Państwowa Szkoła Wyższa im. Papieża Jana Pawła II w Białej Podlaskiej, 2016-01-13) Walczak, Justyna ; Pomastowski, Paweł ; Buszewski, Bogusław

Food as complex mixture of proteins, lipids, vitamins, etc. cannot be separated and identified by using in only one method. This article presents a revision on the hyphenated chromatographic techniques and methods used in food analysis and described main application in food science research, and determination of xenobiotics and their metabolites in environmental. Also article discusses applications of “omics” in food analysis (proteomics, transcriptomics, genomics, metabolomis) and new discipline of - foodomics.
Selected elements of the assessment of eating habits on the example of 2nd and 3rd classes of high school

(Państwowa Szkoła Wyższa im. Papieża Jana Pawła II w Białej Podlaskiej, 2016-01-13) Olejniczak, Dominik ; Pietrzak, Karolina ; Religioni, Urszula ; Gawrońska, Beata

Aim The aim of this paper is the assessment of eating habits of high school students from grades 2 and 3, including eating habits, self-evaluation of diet and the most common nutrition mistakes committed by the members of the studied group. Materials and methodology The study involved 333 high school students between the age of 17 and 19. The group consisted of 150 girls and 183 boys. Data was collected using an original survey which consisted of questions dealing with diet and respondent’s particulars. The study was anonymous. The results have been subjected to statistical analysis using Pearson’s chi-squared test. The statistical differences recognized as significant were those with probability of p<0.05 Results The majority reaching nearly 40% of respondents declared that they eat 4 meals a day. Over 60% eat breakfast every day. The number of students who declared that they do not eat breakfast at all amounted to 48. Over 55% do not pay attention to their eating habits, whereas 45 students consider them unhealthy. About 60% of respondents declare that they do not drink energy drinks. Within the group of students who consume such drinks the most often declared frequency was 1-2 times a week. The answers, however, vary between the female and the male group (chi-square=82.72121, p≤0,05); 75% of males do not consume energy drinks, among females the percentage amounts to mere 43%. Conclusions The students taking part in the study commit nutrition mistakes which might be a sign of unsufficient level of health education within that field. The nutritional education of the youth should start in primary school and be adapted to the needs and possibilities of the target group. In the face of poor diet, it seems justified to analyze the sources of information on nutrition used by the youth in terms of their credibility.
The impact of toothbrush filament design on gingival health during healing. A randomized, controlled, investigator-blinded clinical trial

(Państwowa Szkoła Wyższa im. Papieża Jana Pawła II w Białej Podlaskiej, 2016-01-13) Kovaľová, Eva ; Novák, Bohuslav ; Klamárová, Tatiana ; Eliašová, Anna

Objectives. The primary objective of the study was to test toothbrushes with different types of filaments (conical vs. rounded) with respect to cause gingival abrasion after surgical intervention of wisdom teeth. A secondary objective was to evaluate the efficacy of plaque removal and the improvement of gingival conditions to alleviate wound healing and to avoid gingivitis. Methods. One hundred and seventy-three healthy subjects with surgical intervention of wisdom teeth participated in a randomized, single blind study and were randomly allocated to control group (standard ADA reference toothbrush) or test group (meridol® special toothbrush with conical filaments). Clinical examinations included gingival abrasion, plaque index and gingival index, and were conducted at baseline, 7 and 28 days. Results. For the gingival abrasion the mean number of lesions of all sizes was after 28 days significantly lower in the test group (p-value <0.001) compared to control group. Plaque index was not significantly different between the two groups in the last visit. At day 28 the gingival index was significantly lower in the test group (p=0.031) compared to control group. Conclusions. The toothbrush with conical filaments induced significantly less gingival abrasions than the standard ADA toothbrush and showed superior results in improving gingival health (gingival index). Both toothbrushes were comparable effective with respect to plaque removal. Clinical Relevance. Scientific rationale for study: Supra and sub-gingival biofilm leads to gingival inflammation. Post- surgical removal of the biofilm from gingival surfaces promotes healing after wisdom tooth extraction. Tooth brushing leads to gingival abrasion. Earlier investigations with toothbrushes having conical filaments suggest less gingival tissue damage. Principal findings: The results showed that the toothbrush with conical filaments caused significantly less gingival abrasions than the toothbrush with rounded filaments. Practical implications: : Toothbrush filament design should be considered when choosing toothbrush for oral hygiene after oral surgery.
Physical activity of the students from universities in Biała Podlaska in their free time according to the chosen faculties

(Państwowa Szkoła Wyższa im. Papieża Jana Pawła II w Białej Podlaskiej, 2016-01-13) Niźnikowska, Ewelina ; Stępień, Ewa

The aim of the research was to acquire knowledge about students’ physical activity in their free time according to their chosen faculties. Subject of the research were the students from seven faculties in two universities from Biała Podlaska: computer science, public health, medicine, nursing, tourism and recreation, physiotherapy and PE (physical education) – 548 people in total were the participants. In the work, the method of diagnostic survey based upon the questionnaire technique was applied. Faculty is the aspect that has great impact on the type of chosen forms of physical activities, reasons of its choice, barrier and importance of physical activities in the participants’ lives. Students from such faculties as PE and tourism and recreation show more physical activity in contrast to students from other faculties. More attention should be paid to extension and promotion of physical activity - a very important part of healthy lifestyle - in didactical-educational work of universities.
Physical activity and eating habits among female students from Ukraine

(Państwowa Szkoła Wyższa im. Papieża Jana Pawła II w Białej Podlaskiej, 2016-01-13) Bergier, Józef ; Bergier, Barbara ; Tsos, Anatolii

Physical activity and eating habits are very important determinants of health. The aim of the study is to demonstrate relationship between the level of activity and eating habits of students. The study involved 1,291 female students with an average age of 19.5, from 12 fields of study of the National University in Lutsk, Ukraine. In order to assess the activity levels the authors applied long version of the International Physical Activity Questionnaire (IPAQ), and eating habits were surveyed via a questionnaire prepared at the Institute of Agricultural Medicine in Lublin. With regards to behaviors related to eating habits a significantly higher activity was observed in people suffering from fear of food. In the case of behaviors related to care for the appearance and the figure, a higher physical activity was shown among students performing exercises to reduce and to gain weight. Very insignificant use of the test participants of unhealthy means indicates appropriate health-promoting attitudes of the female students.
The problem of usage of drugs without prescriptions by the youth

(Państwowa Szkoła Wyższa im. Papieża Jana Pawła II w Białej Podlaskiej, 2016-01-13) Szefczyk-Polowczyk, Lucyna ; Zygmunt, Agata ; Respondek, Malwina ; Wengel, Karina

Self-treatment, defined as application of drugs without prescription without consulting your doctor has become a common phenomenon. Easy access to this group of pharmaceutical. advertising campaigns and lack of awareness of adverse effects as a result of incorrect application makes drugs without prescription the medications which have become our first choice. The aim of the study is to assess the problem of the use of over the counter (OTC) drugs by young people living in the Silesian Voivodeship. Material and methods. The study included 180 persons from the Silesian voivodeship at the age of 18-30. The research tool was an author’s, anonymous questionnaire. The questions included within it concerned, among others: frequency, form and side effects of drugs applied without prescription. Results. Despite the fact that the majority of respondents (57%) assess their health state as good, the overwhelming number of people (91%) report applying medications without a prescription. The most popular OTC pharmaceutical products include painkillers and vitamins. One in five respondents (20%) admits that he or she consumes more medication than it is recommended in the package leaflet. Conclusions. Very good and good health state declared by the respondents does not exclude accepting their medication without prescription. In case of treatment of intermittent or mild symptoms, the use of medications without a prescription – saves patient’s time and unburdens health care system. This phenomenon, however, is a challenge for the public health sector. Actions must be undertaken which are aimed at raising consumers-patients' awareness regarding the dangers posed by improper use of OTC drugs.
Dizziness – pathogenesis, diagnosis and treatment

(Państwowa Szkoła Wyższa im. Papieża Jana Pawła II w Białej Podlaskiej, 2016-01-13) Tomaszewski, Marek ; Banakiewicz, Katarzyna ; Jajko, Krzysztof ; Szypowski, Roman ; Zieliński, Paweł ; Zalewski, Grzegorz ; Olchowik, Grażyna

Dizziness is a symptom of many diseases. Patients very frequently come with such ailment to the hospital emergency department. It is a state which may last a few seconds or minutes and increase or recede with time. Therefore, the admitted patients frequently cannot assess their own illness in a precise and objective way. The dizziness definition is also quite ambiguous. Dizziness is defined as the sensation of one own’s body movement or spinning and movement of the surrounding. It is very important to record the patient’s medical history since the diagnostic procedure may depend on the symptoms’ character. Dizziness may be a symptom of a serious disease, although it is not easy to find its cause. It appears not only in case of the labyrinth and nervous system disorders, but also in the systemic and functional diseases. Dizziness and balance disorder are the direct cause of admitting one in every thirty patients. The symptom indicated the directly life-threatening disease only within the 3-8.5% of patients (cerebral circulation insufficiency - 6%, cardiac dysrhythmia - 1.5%, brain tumour < 1%). Analyzing the data concerning the problem of dizziness occurrence within the general population, it has been noticed that this symptom has been reported two or three times more frequent by women than by men. Dizzinesses are classified pathogenetically and clinically into labyrinthine and non-labyrinthine, paroxysmal and permanent, acute and chronic. Dizziness is hard to diagnose because the symptoms reported by patients are only their own subjective sensations. The data presented in the article implicate the increasing number of patients with such disorders. Apart from dizziness, the patients complain also about the hearing disorders and nausea, which make their proper functioning impossible. It is inappropriate to start the treatment without knowing the cause. Establishing, on the basis of patient’s medical history and physical examination, whether the dizziness is of peripheral or central origin, is essential for the further diagnosis. After establishing the main diagnosis, the casual
The airway obstruction - important abrupt condition for pediatrics

(Państwowa Szkoła Wyższa im. Papieża Jana Pawła II w Białej Podlaskiej, 2016-01-13) Tomaszewski, Marek ; Banakiewicz, Katarzyna ; Jajko, Krzysztof ; Szypowski, Roman ; Zieliński, Paweł ; Zalewski, Grzegorz ; Spisacka, Stanisława ; Olchowik, Grażyna

The ability of fast response in case of increasing health problems of a child which lead directly to life-threatening situations is a necessary condition for creating opportunity of child’s survival until it will be transported to intensive care unit, where it will be provided with care by a specialist. In case of healthy children the most common cause of acute respiratory fa ilure is obstruction of upper respiratory tract. There is an enormous variety of causes of upper airway obstruction, but the most important are the result of congenital defects, acute inflammation, anaphylactic reactions, foreign body aspiration and injuries. Consequence of the hypoventilation resulting from significant impediment of airflow through the obstructed airways is impa ired gas exchange in the lungs. This leads to the increasing hypoxemia (PaO 2 <60 mmHg) and hypercapnia (PaCO2> 45 mmHg). This condition is called the total respiratory failure. The persistence of hypoventilation leads to hypoxia of vital organs (heart muscle, brain), increased anaerobic metabolism, acidosis, and inevitably to cardiac arrest as a result of homeostasis disorders. Respiratory failure is defined as acute when developing suddenly and is potentially reversible. We can find such a situation in the fast-increasing stenosis of the larynx. Symptoms of severe dyspnoea occur in a short time, but can be interrupted by an effective airway patency. Acute respiratory failure is a state of direct threat to life, which is why it is crucial to give a prompt aid to the sick child. The aim of this paper is to discuss the signs and symptoms, knowledge of which is essential for rapid identification and initial differentiation of the causes of acute upper airway obstruction in children. The principles of first-aid for children with acute respiratory failure and above all the description of life-saving procedures will be presented.
Concentration of some amino acids in blood plasma and study results of lumbosacral bone system computer tomography

(Państwowa Szkoła Wyższa im. Papieża Jana Pawła II w Białej Podlaskiej, 2016-01-13) Wójcik, Gustaw ; Sokołowska, Barbara ; Borzęcki, Andrzej

Summary: Introduction and objective: Back pain are the most common ailment within the human locomotor system. Because of their prevalence, they were classified as diseases of civilization. The aim of the study was to attempt to assess the concentration of selected amino acids in plasma and correlating the results of laboratory tests with the occurrence of backaches. Material and method: The study group included 188 patients presenting for CT scan administering as the cause of their symptoms low back pains. All of these patients gave the blood samples from which the concentration of free amino acids was estimated by ion exchange chromatography using an automated amino acid analyzer AAA 400 from INGOS Praha. The control group consisted of patients who underwent testing using computed tomography and there were no primary or secondary changes associated with degeneration in the lumbar spine. Results: Patients on the basis of research carried out by computed tomography were divided into five groups according to disease entity. Analyzing the average concentration of essential amino acids in the blood plasma of patients of each group, it was found that it is higher in the case of lysine for each considered disease entity. The average concentration of methionine in all disease entities does not deviate from the average values in the control group. Analysis of the average concentration of selected essential amino acids revealed that in the case presented disorders underwent their level of variation. Average concentrations of selected amino acids have proven to be very similar in both groups. Slightly higher values proved to be in the control group for proline and lysine. Conclusions: The concentration of amino acids varies with the severity of degenerative changes in the connections as well as in interbody joints. The highest increase in the concentrations of all tested amino acids appears in cancer.
The evaluation of topography Borrelia burgdorferi by atomic force microscope (AFM)

(Państwowa Szkoła Wyższa im. Papieża Jana Pawła II w Białej Podlaskiej, 2016-01-13) Tokarska-Rodak, Małgorzata ; Kozioł-Montewka, Maria

The aim of the present work was to evaluate the topography of spirochetes’ cells Borrelia burgdorferi s.s. B31 in atomic force microscope (AFM). Results: The length of spirochetes B. burgdorferi has ranged between 15.38-22.68µm. The cells of spirochetes do not constitute structures of a fixed diameter and height. Thus, in order to identify real parameters of cells, the horizontal distance and vertical distance have been used in the measurements. The average value of a spirochetes’ diameter has been estimated by taking series of measures and it is 0.40 μm. The average value of a spirochetes’ height has been estimated by taking series of measures and it is 70.14 nm. The analysis of a relation between measured parameters of spirochetes: diameter and height revealed that along with the growth of diameter of a bacteria cell, its height also grows. The average value of a fibers’ diameter has been estimated by taking series of measurements and it is 0.09 μm and the average height of fibers was 7.91 nm. Conclusions: The atomic force microscope (AFM) is a modern tool with a broad spectrum of observatory and measure abilities and is a technique which has been used in biology and microbiology to investigate the topography of surface and in the evaluation properties of cells.
The presence of interfering antibodies in selected control sera on the example of a set for determination of tPSA

(Państwowa Szkoła Wyższa im. Papieża Jana Pawła II w Białej Podlaskiej, 2016-01-13) Hajdrowska, Bogumiła ; Krzakiewicz, Katarzyna ; Czubasiewicz, Zofia ; Strzelczyk, Joanna Katarzyna ; Szewczyk, Marek ; Brus, Ryszard

The human sera often contain substances which interfere in the course of immunochemical reactions. It is essential for the control sera used to determine concentrations of antigen of the prostate not to contain such ingredients. The aim of this study was to test the control sera, three producers, containing low (N) and high (P) concentrations of prostate antigen (tPSA). As a factor blocking the interfering actions, the TRU Bloc Meridian Life Science, Inc. reagent was used which contains antibodies against mouse protein and rheumatoid factor. The sera with a low concentration of tPSA demonstrated the presence of interfering substances.
The efficacy of combination therapy with lenalidomide and dexamethasone in the treatment of relapsed multiple myeloma

(Państwowa Szkoła Wyższa im. Papieża Jana Pawła II w Białej Podlaskiej, 2016-01-13) Szudy-Szczyrek, Aneta ; Legieć, Wojciech ; Mańko, Joanna ; Gmyz, Katarzyna ; Szczyrek, Michał ; Hus, Marek

Multiple myeloma is a neoplastic disease which is characterised by proliferation of monoclonal plasmocytes in the bone marrow. It is the second most common hematologic cancer and it represents 1% of all cancer deaths. Despite enormous development in multiple myeloma biology and treatment over the last 30 years - it is still incurable disease with a median survival of 50 – 55 months. Currently, one of the most important goals in the treatment of multiple myeloma is to achieve long-term control of the disease, without negative impact on the patient’s quality of life. Thanks to therapeutic regimens based on new immunomodulatory drugs, this aim seems to be achievable. In this paper we present the case of a female patient living with multiple myeloma for 14 years. Initially patient was treated with standard VAD (vincristine, doxorubicin, dexamethasone) chemotherapy regimen. After a nearly complete remission of the disease, autotransplantation of hematopoietic cells was performed. One year after transplantation there was a relapse of the disease. In the treatment of relapse it was decided to use scheme based on lenalidomide and dexamethasone. After 4th cycle of treatment, a complete remission was achieved. So far, the patient received 149 cycles. In the evaluation of minimal residual disease still maintains a state of complete remission maintains. During over 12 years of treatment no complications in grade 3 and 4 of the CTCAE v.4 was observed. Currently the patient is 58 years old, she still receives lenalidomide and leads moderately active life.
Acute aortic dissection – case description

(Państwowa Szkoła Wyższa im. Papieża Jana Pawła II w Białej Podlaskiej, 2016-01-13) Wójcik, Gustaw ; Piskorz, Jolanta

Aortic dissection is a tearing in the inner wall of the aorta which spreads along the wall of the vessel. Acute aortic dissection is one of acute aortic syndromes, that is, sudden clinical conditions which are associated with abnormalities of the aortic wall and threaten patient’s life. It is estimated that the number of aortic dissections in Poland amounts to around 1000 cases per year. The symptoms of aortic dissection are so equivocal that they may suggest other diseases of various organs in the thorax and abdominal cavity. The described case of a 57-year-old man is an example of a complication of hypertension which, as a result of an isometrical physical effort, caused tearing of an inner membrane and forming of an aortic dissection of type I in the DeBakey classification. After performing medical imagining the patient with the diagnosis of aortic dissection, hematoma in the pseudoaneurysm cavity and renal infarction was submitted to emergency cardiac surgery. The diagnostics and selection of a place at cardiac surgery were carried out within an hour. However, the surgery did not take place, because the patient died due to a circulatory collapse. Acute aortic dissection is subject to high mortality rate during the first hour since the onset of symptoms. Therefore, rapid recognition is crucial for the further prognosis of the patient.
Some results of an analysis of polyhydric alcohols effect on detoxication processes

(Państwowa Szkoła Wyższa im. Papieża Jana Pawła II w Białej Podlaskiej, 2016-01-13) Konovchuk, Viktor

Rheosorbilact action on antitoxic function of the kidneys has been analysed using the values of medium weight molecules in patients with severe sepsis. The study design includes the criteria of inclusion, exclusion and cessation. Patients with pyoceptic complications (mainly surgical abdominal sepsis) with signs of severe endotoxicosis, dopaminergic activity (5-10 mcg/kg min), biochemical criteria of SS (lactate >4 mmole/l, С-reactive protein >2 standard departures from the norm) and other signs of severe sepsis with generalized disorders in homeostasis (assessing the multiple organ damage course by H.Celye-I.A. Yeriuhin scale- 20-27 points, MODS scale – 6-10 points) corresponded to the inclusion criterion. All patients were provided with appropriate debridement and intensive traditional therapy. For control studies we involved patients with systemic inflammatory response syndrome who had 2-3 signs of SIRS in stage A. It was found that rheosorbilact activates the transportation of medium weight molecules out of the extracellular space and increases their excretion by the renal nephrons in patients with severe sepsis. It was established that in severe sepsis rheosorbilact provides a high level of excretion of medium weight molecules by suppressing processes of reabsorption in the proximal nephron portions caused by peptidase dependent metabolism.
The importance of metagenomics research in human ecological niches and their role in the diagnosis of noninfectious diseases

(Państwowa Szkoła Wyższa im. Papieża Jana Pawła II w Białej Podlaskiej, 2016-01-13) Weiner, Marcin ; Kubajka, Maria

Human body is a complex system that is affected by a significant number of microscopic organisms called the microbiomes. The dynamic development of science has led to innovative discoveries in the field of microbiology. This in turn has extracted new field, metagenomics, thanks to which it became possible to perform detailed analysis of individual groups of bacteria and to determine their effects on preserving a good health. One of the biggest scientific projects that would investigate the influence of microbiomes on humans is HMP (Human Microbiome Project). As part of it the research is being conducted leading to characterize human microbiome at the level of nucleotide sequence of the entire genomic DNA. The microflora of the skin, oral cavity, respiratory tract, digestive tract (intestines), genitourinary system has an essential role in the homeostasis. In the last year the carried research proved that it is a vital part of the human organism in preserving a good health. Any changes in its composition may lead to systemic diseases. Pathological changes affect the outcome of the interaction within the microflora that includes species of commensal and pathogenic bacteria, as well as immunology and genetics of the host. Metagenomics research will contribute not only to the recognition of new, so far unidentified by the bacteriological methods microorganisms, but most of all they will serve as a basis to understand the relationships between the human organism and in-dwelling microorganisms. Thanks to the development of the metagenomics or the NGS (Next Generation Sequencing) it will be possible to discover new metabolic pathways and bidirectional links of bacteria with human metabolism. This will help in finding new therapeutic methods in the treatment of many noninfectious diseases so far considered as civilization diseases or genetically conditioned.

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