2020, Volume 14, Issue 1

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https://hdl.handle.net/20.500.13044/276

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Przeglądanie 2020, Volume 14, Issue 1 według Temat "bovine tuberculosis"
  • Rekord
    Analysis of resistance to antimycobacterial drugs among MTBC strains isolated from cattle in Poland as a threat to human health
    (Państwowa Szkoła Wyższa im. Papieża Jana Pawła II w Białej Podlaskiej, 2020-02-24) Weiner, Marcin ; Krajewska, Monika ; Zabost, Anna ; Augustynowicz-Kopeć, Ewa ; Szulowski, Krzysztof
    Background. Tuberculosis is a highly contagious disease affecting humans and animals. It is caused by mycobacteria that are part of the Mycobacterium tuberculosis complex (MTBC). The etiological agent causing bovine tuberculosis is mycobacteria bovis: Mycobacterium bovis and Mycobacterium caprae. According to the World Health Organization bovine tuberculosis is classified as direct zoonosis. Material and methods. T he s tudy m aterial c onsisted o f 1 29 M TBC s trains i solated f rom Polish cattle, which were microbiologically analyzed. The resistance phenotype was tested for first-line anti-tuberculosis drugs used in the treatment of tuberculosis in humans. The drugs included streptomycin, isoniazid, rifampicin, ethambutol, and pyrazinamide. The MTBC strains tested in this study were isolated from cattle tissue post mortem so that the determination of drug resistance could meet only the epidemiological criterion. Results. Polish strains of mycobacteria bovis have not acquired environmental resistance despite the huge dynamics of changes in the phenotype of mycobacterial tuberculosis resistance. Strains classified as M. bovis are characterized by natural resistance to PZA, which is typical of this species. Conclusions. Drug resistance imposes the use of additional drugs. Drugs that are less effective than the basic drugs, drugs causing side effects more frequently and drugs that are much more expensive.