2015, Volume 9, Issue 2

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https://hdl.handle.net/20.500.13044/2156

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Przeglądanie 2015, Volume 9, Issue 2 według Tytuł

  • Rekord
    Acute aortic dissection – case description
    (Państwowa Szkoła Wyższa im. Papieża Jana Pawła II w Białej Podlaskiej, 2016-01-13) Wójcik, Gustaw ; Piskorz, Jolanta
    Aortic dissection is a tearing in the inner wall of the aorta which spreads along the wall of the vessel. Acute aortic dissection is one of acute aortic syndromes, that is, sudden clinical conditions which are associated with abnormalities of the aortic wall and threaten patient’s life. It is estimated that the number of aortic dissections in Poland amounts to around 1000 cases per year. The symptoms of aortic dissection are so equivocal that they may suggest other diseases of various organs in the thorax and abdominal cavity. The described case of a 57-year-old man is an example of a complication of hypertension which, as a result of an isometrical physical effort, caused tearing of an inner membrane and forming of an aortic dissection of type I in the DeBakey classification. After performing medical imagining the patient with the diagnosis of aortic dissection, hematoma in the pseudoaneurysm cavity and renal infarction was submitted to emergency cardiac surgery. The diagnostics and selection of a place at cardiac surgery were carried out within an hour. However, the surgery did not take place, because the patient died due to a circulatory collapse. Acute aortic dissection is subject to high mortality rate during the first hour since the onset of symptoms. Therefore, rapid recognition is crucial for the further prognosis of the patient.
  • Rekord
    Features of pharmacotherapy of hepatic encephalopathy manifestations in liver cirrhosis
    (Państwowa Szkoła Wyższa im. Papieża Jana Pawła II w Białej Podlaskiej, 2016-01-13) Meretskyi, Viktor ; Lobanets, Natalya
    The aim of this work is to study the effect of drug mebikar on the clinical manifestations of hepatic encephalopathy in patients with liver cirrhosis. The study involved 34 patients with cirrhosis of different etiologies. The average age of the examined patients was (48.5±0.9) years, that prevailed patients of working age, indicating the medical and social significance of the problem of early diagnosis and adequate treatment of cirrhosis. One of the most frequent complications of cirrhosis is hepatic encephalopathy. In addition to conventional clinical and laboratory findings in patients with liver cirrhosis, severities of hepatic encephalopathy were determined according to West-Haven criteria before and after treatment. In patients with liver cirrhosis was established the presence of latent or clinically expressed hepatic encephalopathy. The treatment of the control group of patients consisted of the following drugs: essential phospholipids, mixture of sorbitol and major ions, arginine glutamate, furosemide, verospiron, lactulose, amoxicillin trihydrate and lansoprazole. In the complex treatment of the main group of patients medicine mebikar was administered additionally. Analysis of the clinical manifestations of hepatic encephalopathy showed a marked improvement in patients who received additional treatment with mebikar. Specifically, the incidences of mood changes as well as anxiety decreased in this group on average of 38% compared with those patients without an additional treatment with mebikar. Also, sleep disturbances in the main group was observed to be lower by 7.2% compared to those in the control group. Inclusion in the treatment of patients with liver cirrhosis, the drug mebikar – a daytime tranquilizer with anxiolytic properties reduces neurotic disorders, improves emotional state which may indicate a regression in the manifestations of hepatic encephalopathy thereby improving the quality of life of patientsand thus substantiating an expedient inclusion of mebikar an anxiolytic drug to the complex therapy of patients with liver cirrhosis.
  • Rekord
    Healthy Smile Prevention Project in Slovakia with students DH Klinik in Presov. Final report of study: cariosity of teeth among schoolchildren within two groups in Slovakia in 2002, 2005, 2007 and 2009
    (Państwowa Szkoła Wyższa im. Papieża Jana Pawła II w Białej Podlaskiej, 2016-01-13) Kovaľová, Eva ; Eliašová, Anna ; Adamišin, Peter ; Koval, Alexander
    Summary: In the thesis the authors present complex results of the epidemiological study of oral health of the 6 - 12-year old schoolchildren attending elementary schools in Prešov (Slovakia) who participated in the Healthy Smile Prevention Project. The participants of the Project were represented by the pre-school children and schoolchildren from the age of 4 years attending the pre-school facilities and elementary schools and the project was performed by the dental hygienist, dental disease prevention officer, and school dental care assistant under supervision of a dental practitioner. The oral health of the abovementioned project participants was compared with the oral health of the group of children not participating in the prevention project. The project was supported by the Swiss company GABA.
  • Rekord
    Is it possible to detect lung cancer by trained dogs?
    (Państwowa Szkoła Wyższa im. Papieża Jana Pawła II w Białej Podlaskiej, 2016-01-13) Rudnicka, Joanna ; Walczak, Marta ; Jezierski, Tadeusz ; Buszewski, Bogusław
    During the illness are released volatile organic compounds with specific smell which could have in diagnosis of diseases. The first aim of the study was qualitative and quantitative analysis of exhaled breath samples obtained from patients with lung cancer, healthy volunteers and people with other lung diseases by gas chromatography-mass spectrometry. This study showed that twenty compounds propane, ethanol, isobutane, butane, propanal, 1-propanol, 2-propanol, 2-methylfuran, 2-butanone, benzene, 2-pentanone, pentanal, hexanal, cyclohexanone, 4-heptanone, 2,4-dimethylheptane, 2,3,4-trimethylhexane, 2,3,5-trimethylhexane, 4-methyloctane, α-pinene separated two research groups of patients and healthy controls. The second goal was to evaluate the sensitivity and specificity of canine scent detection using 5 station scent lineup. Among lung cancer patients and complementary samples, overall sensitivity of canine scent detection was 85.54%, while specificity was 71.84%.
  • Rekord
    Physical activity and eating habits among female students from Ukraine
    (Państwowa Szkoła Wyższa im. Papieża Jana Pawła II w Białej Podlaskiej, 2016-01-13) Bergier, Józef ; Bergier, Barbara ; Tsos, Anatolii
    Physical activity and eating habits are very important determinants of health. The aim of the study is to demonstrate relationship between the level of activity and eating habits of students. The study involved 1,291 female students with an average age of 19.5, from 12 fields of study of the National University in Lutsk, Ukraine. In order to assess the activity levels the authors applied long version of the International Physical Activity Questionnaire (IPAQ), and eating habits were surveyed via a questionnaire prepared at the Institute of Agricultural Medicine in Lublin. With regards to behaviors related to eating habits a significantly higher activity was observed in people suffering from fear of food. In the case of behaviors related to care for the appearance and the figure, a higher physical activity was shown among students performing exercises to reduce and to gain weight. Very insignificant use of the test participants of unhealthy means indicates appropriate health-promoting attitudes of the female students.
  • Rekord
    Physical activity of the students from universities in Biała Podlaska in their free time according to the chosen faculties
    (Państwowa Szkoła Wyższa im. Papieża Jana Pawła II w Białej Podlaskiej, 2016-01-13) Niźnikowska, Ewelina ; Stępień, Ewa
    The aim of the research was to acquire knowledge about students’ physical activity in their free time according to their chosen faculties. Subject of the research were the students from seven faculties in two universities from Biała Podlaska: computer science, public health, medicine, nursing, tourism and recreation, physiotherapy and PE (physical education) – 548 people in total were the participants. In the work, the method of diagnostic survey based upon the questionnaire technique was applied. Faculty is the aspect that has great impact on the type of chosen forms of physical activities, reasons of its choice, barrier and importance of physical activities in the participants’ lives. Students from such faculties as PE and tourism and recreation show more physical activity in contrast to students from other faculties. More attention should be paid to extension and promotion of physical activity - a very important part of healthy lifestyle - in didactical-educational work of universities.
  • Rekord
    Some results of an analysis of polyhydric alcohols effect on detoxication processes
    (Państwowa Szkoła Wyższa im. Papieża Jana Pawła II w Białej Podlaskiej, 2016-01-13) Konovchuk, Viktor
    Rheosorbilact action on antitoxic function of the kidneys has been analysed using the values of medium weight molecules in patients with severe sepsis. The study design includes the criteria of inclusion, exclusion and cessation. Patients with pyoceptic complications (mainly surgical abdominal sepsis) with signs of severe endotoxicosis, dopaminergic activity (5-10 mcg/kg min), biochemical criteria of SS (lactate >4 mmole/l, С-reactive protein >2 standard departures from the norm) and other signs of severe sepsis with generalized disorders in homeostasis (assessing the multiple organ damage course by H.Celye-I.A. Yeriuhin scale- 20-27 points, MODS scale – 6-10 points) corresponded to the inclusion criterion. All patients were provided with appropriate debridement and intensive traditional therapy. For control studies we involved patients with systemic inflammatory response syndrome who had 2-3 signs of SIRS in stage A. It was found that rheosorbilact activates the transportation of medium weight molecules out of the extracellular space and increases their excretion by the renal nephrons in patients with severe sepsis. It was established that in severe sepsis rheosorbilact provides a high level of excretion of medium weight molecules by suppressing processes of reabsorption in the proximal nephron portions caused by peptidase dependent metabolism.
  • Rekord
    The efficacy of combination therapy with lenalidomide and dexamethasone in the treatment of relapsed multiple myeloma
    (Państwowa Szkoła Wyższa im. Papieża Jana Pawła II w Białej Podlaskiej, 2016-01-13) Szudy-Szczyrek, Aneta ; Legieć, Wojciech ; Mańko, Joanna ; Gmyz, Katarzyna ; Szczyrek, Michał ; Hus, Marek
    Multiple myeloma is a neoplastic disease which is characterised by proliferation of monoclonal plasmocytes in the bone marrow. It is the second most common hematologic cancer and it represents 1% of all cancer deaths. Despite enormous development in multiple myeloma biology and treatment over the last 30 years - it is still incurable disease with a median survival of 50 – 55 months. Currently, one of the most important goals in the treatment of multiple myeloma is to achieve long-term control of the disease, without negative impact on the patient’s quality of life. Thanks to therapeutic regimens based on new immunomodulatory drugs, this aim seems to be achievable. In this paper we present the case of a female patient living with multiple myeloma for 14 years. Initially patient was treated with standard VAD (vincristine, doxorubicin, dexamethasone) chemotherapy regimen. After a nearly complete remission of the disease, autotransplantation of hematopoietic cells was performed. One year after transplantation there was a relapse of the disease. In the treatment of relapse it was decided to use scheme based on lenalidomide and dexamethasone. After 4th cycle of treatment, a complete remission was achieved. So far, the patient received 149 cycles. In the evaluation of minimal residual disease still maintains a state of complete remission maintains. During over 12 years of treatment no complications in grade 3 and 4 of the CTCAE v.4 was observed. Currently the patient is 58 years old, she still receives lenalidomide and leads moderately active life.
  • Rekord
    The importance of metagenomics research in human ecological niches and their role in the diagnosis of noninfectious diseases
    (Państwowa Szkoła Wyższa im. Papieża Jana Pawła II w Białej Podlaskiej, 2016-01-13) Weiner, Marcin ; Kubajka, Maria
    Human body is a complex system that is affected by a significant number of microscopic organisms called the microbiomes. The dynamic development of science has led to innovative discoveries in the field of microbiology. This in turn has extracted new field, metagenomics, thanks to which it became possible to perform detailed analysis of individual groups of bacteria and to determine their effects on preserving a good health. One of the biggest scientific projects that would investigate the influence of microbiomes on humans is HMP (Human Microbiome Project). As part of it the research is being conducted leading to characterize human microbiome at the level of nucleotide sequence of the entire genomic DNA. The microflora of the skin, oral cavity, respiratory tract, digestive tract (intestines), genitourinary system has an essential role in the homeostasis. In the last year the carried research proved that it is a vital part of the human organism in preserving a good health. Any changes in its composition may lead to systemic diseases. Pathological changes affect the outcome of the interaction within the microflora that includes species of commensal and pathogenic bacteria, as well as immunology and genetics of the host. Metagenomics research will contribute not only to the recognition of new, so far unidentified by the bacteriological methods microorganisms, but most of all they will serve as a basis to understand the relationships between the human organism and in-dwelling microorganisms. Thanks to the development of the metagenomics or the NGS (Next Generation Sequencing) it will be possible to discover new metabolic pathways and bidirectional links of bacteria with human metabolism. This will help in finding new therapeutic methods in the treatment of many noninfectious diseases so far considered as civilization diseases or genetically conditioned.
  • Rekord
    The presence of interfering antibodies in selected control sera on the example of a set for determination of tPSA
    (Państwowa Szkoła Wyższa im. Papieża Jana Pawła II w Białej Podlaskiej, 2016-01-13) Hajdrowska, Bogumiła ; Krzakiewicz, Katarzyna ; Czubasiewicz, Zofia ; Strzelczyk, Joanna Katarzyna ; Szewczyk, Marek ; Brus, Ryszard
    The human sera often contain substances which interfere in the course of immunochemical reactions. It is essential for the control sera used to determine concentrations of antigen of the prostate not to contain such ingredients. The aim of this study was to test the control sera, three producers, containing low (N) and high (P) concentrations of prostate antigen (tPSA). As a factor blocking the interfering actions, the TRU Bloc Meridian Life Science, Inc. reagent was used which contains antibodies against mouse protein and rheumatoid factor. The sera with a low concentration of tPSA demonstrated the presence of interfering substances.