2015, Volume 9, Issue 2
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RekordThe presence of interfering antibodies in selected control sera on the example of a set for determination of tPSA(Państwowa Szkoła Wyższa im. Papieża Jana Pawła II w Białej Podlaskiej, 2016-01-13)The human sera often contain substances which interfere in the course of immunochemical reactions. It is essential for the control sera used to determine concentrations of antigen of the prostate not to contain such ingredients. The aim of this study was to test the control sera, three producers, containing low (N) and high (P) concentrations of prostate antigen (tPSA). As a factor blocking the interfering actions, the TRU Bloc Meridian Life Science, Inc. reagent was used which contains antibodies against mouse protein and rheumatoid factor. The sera with a low concentration of tPSA demonstrated the presence of interfering substances.
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RekordThe efficacy of combination therapy with lenalidomide and dexamethasone in the treatment of relapsed multiple myeloma(Państwowa Szkoła Wyższa im. Papieża Jana Pawła II w Białej Podlaskiej, 2016-01-13)Multiple myeloma is a neoplastic disease which is characterised by proliferation of monoclonal plasmocytes in the bone marrow. It is the second most common hematologic cancer and it represents 1% of all cancer deaths. Despite enormous development in multiple myeloma biology and treatment over the last 30 years - it is still incurable disease with a median survival of 50 – 55 months. Currently, one of the most important goals in the treatment of multiple myeloma is to achieve long-term control of the disease, without negative impact on the patient’s quality of life. Thanks to therapeutic regimens based on new immunomodulatory drugs, this aim seems to be achievable. In this paper we present the case of a female patient living with multiple myeloma for 14 years. Initially patient was treated with standard VAD (vincristine, doxorubicin, dexamethasone) chemotherapy regimen. After a nearly complete remission of the disease, autotransplantation of hematopoietic cells was performed. One year after transplantation there was a relapse of the disease. In the treatment of relapse it was decided to use scheme based on lenalidomide and dexamethasone. After 4th cycle of treatment, a complete remission was achieved. So far, the patient received 149 cycles. In the evaluation of minimal residual disease still maintains a state of complete remission maintains. During over 12 years of treatment no complications in grade 3 and 4 of the CTCAE v.4 was observed. Currently the patient is 58 years old, she still receives lenalidomide and leads moderately active life.
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RekordThe importance of metagenomics research in human ecological niches and their role in the diagnosis of noninfectious diseases(Państwowa Szkoła Wyższa im. Papieża Jana Pawła II w Białej Podlaskiej, 2016-01-13)Human body is a complex system that is affected by a significant number of microscopic organisms called the microbiomes. The dynamic development of science has led to innovative discoveries in the field of microbiology. This in turn has extracted new field, metagenomics, thanks to which it became possible to perform detailed analysis of individual groups of bacteria and to determine their effects on preserving a good health. One of the biggest scientific projects that would investigate the influence of microbiomes on humans is HMP (Human Microbiome Project). As part of it the research is being conducted leading to characterize human microbiome at the level of nucleotide sequence of the entire genomic DNA. The microflora of the skin, oral cavity, respiratory tract, digestive tract (intestines), genitourinary system has an essential role in the homeostasis. In the last year the carried research proved that it is a vital part of the human organism in preserving a good health. Any changes in its composition may lead to systemic diseases. Pathological changes affect the outcome of the interaction within the microflora that includes species of commensal and pathogenic bacteria, as well as immunology and genetics of the host. Metagenomics research will contribute not only to the recognition of new, so far unidentified by the bacteriological methods microorganisms, but most of all they will serve as a basis to understand the relationships between the human organism and in-dwelling microorganisms. Thanks to the development of the metagenomics or the NGS (Next Generation Sequencing) it will be possible to discover new metabolic pathways and bidirectional links of bacteria with human metabolism. This will help in finding new therapeutic methods in the treatment of many noninfectious diseases so far considered as civilization diseases or genetically conditioned.
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RekordAcute aortic dissection – case description(Państwowa Szkoła Wyższa im. Papieża Jana Pawła II w Białej Podlaskiej, 2016-01-13)Aortic dissection is a tearing in the inner wall of the aorta which spreads along the wall of the vessel. Acute aortic dissection is one of acute aortic syndromes, that is, sudden clinical conditions which are associated with abnormalities of the aortic wall and threaten patient’s life. It is estimated that the number of aortic dissections in Poland amounts to around 1000 cases per year. The symptoms of aortic dissection are so equivocal that they may suggest other diseases of various organs in the thorax and abdominal cavity. The described case of a 57-year-old man is an example of a complication of hypertension which, as a result of an isometrical physical effort, caused tearing of an inner membrane and forming of an aortic dissection of type I in the DeBakey classification. After performing medical imagining the patient with the diagnosis of aortic dissection, hematoma in the pseudoaneurysm cavity and renal infarction was submitted to emergency cardiac surgery. The diagnostics and selection of a place at cardiac surgery were carried out within an hour. However, the surgery did not take place, because the patient died due to a circulatory collapse. Acute aortic dissection is subject to high mortality rate during the first hour since the onset of symptoms. Therefore, rapid recognition is crucial for the further prognosis of the patient.
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RekordSome results of an analysis of polyhydric alcohols effect on detoxication processes(Państwowa Szkoła Wyższa im. Papieża Jana Pawła II w Białej Podlaskiej, 2016-01-13)Rheosorbilact action on antitoxic function of the kidneys has been analysed using the values of medium weight molecules in patients with severe sepsis. The study design includes the criteria of inclusion, exclusion and cessation. Patients with pyoceptic complications (mainly surgical abdominal sepsis) with signs of severe endotoxicosis, dopaminergic activity (5-10 mcg/kg min), biochemical criteria of SS (lactate >4 mmole/l, С-reactive protein >2 standard departures from the norm) and other signs of severe sepsis with generalized disorders in homeostasis (assessing the multiple organ damage course by H.Celye-I.A. Yeriuhin scale- 20-27 points, MODS scale – 6-10 points) corresponded to the inclusion criterion. All patients were provided with appropriate debridement and intensive traditional therapy. For control studies we involved patients with systemic inflammatory response syndrome who had 2-3 signs of SIRS in stage A. It was found that rheosorbilact activates the transportation of medium weight molecules out of the extracellular space and increases their excretion by the renal nephrons in patients with severe sepsis. It was established that in severe sepsis rheosorbilact provides a high level of excretion of medium weight molecules by suppressing processes of reabsorption in the proximal nephron portions caused by peptidase dependent metabolism.