Review of research on alcohol dependence in a model of mice selected for high and low stress-induced analgesia

dc.contributor.author Poznański, Piotr
dc.contributor.author Leśniak, Anna
dc.contributor.author Strzemecka, Joanna
dc.contributor.author Sacharczuk, Mariusz
dc.date.accessioned 2022-02-03T08:23:31Z
dc.date.available 2022-02-03T08:23:31Z
dc.date.issued 2018-07-24
dc.description.abstract Decades of studies on alcohol dependence showed that it is a very complex and multifactorial disorder. Several receptor systems are involved in development and susceptibility to alcohol abuse; however, there are some which play a crucial role in its pathogenesis, e.g. dopaminergic or opioid system. In this paper, an effort is made to explain the role of endogenous opioid system activity in alcohol dependence. To achieve the goal, we use a unique model is used which shows mice lines that are divergently selected for high (HA) and low (LA) stress-induced analgesia. This process allowed for selecting individuals characterised by hyperactive (HA) or hypoactive (LA) opioid system. Basing on the performed experiments, we proved that delta opioid receptors play a critical role in the development of addiction. The most notable achievement is an unspecific reaction of mice with the hyperactive opioid system to naloxone – an unspecific opioid system antagonist, which is currently approved in the pharmacotherapy of dependent patients.
dc.identifier.citation Poznański P, Leśniak A, Strzemecka J, Sacharczuk M. Review of research on alcohol dependence in a model of mice selected for high and low stress-induced analgesia. Health Prob Civil. 2018; 12(3): 217-222. https://doi.org/10.5114/hpc.2018.76747
dc.identifier.issn 2353-6942
dc.identifier.uri https://hdl.handle.net/20.500.13044/530
dc.language.iso en
dc.publisher Państwowa Szkoła Wyższa im. Papieża Jana Pawła II w Białej Podlaskiej
dc.title Review of research on alcohol dependence in a model of mice selected for high and low stress-induced analgesia
dc.type Article
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