2019, Volume 13, Issue 1

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https://hdl.handle.net/20.500.13044/451

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Przeglądanie 2019, Volume 13, Issue 1 według Autor "Gut-Lepiech, Agata"
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    Antagonistic interaction of lacosamide with carbamazepine and valproate in the mouse tonic-clonic seizure model
    (Państwowa Szkoła Wyższa im. Papieża Jana Pawła II w Białej Podlaskiej, 2019-01-30) Kondrat-Wróbel, Maria W. ; Załuska, Katarzyna ; Walczak, Aleksandra ; Panasiuk-Poterek, Anna N. ; Gut-Lepiech, Agata ; Wróblewska-Łuczka, Paula ; Łuszczki, Jarogniew J.
    Background. It is estimated that approximately 1% of people worldwide suffer from epilepsy. Currently available antiepileptic drugs (AEDs) are able to control epileptic seizures in about 70% of cases. In the remaining patients (30%), the application of two or three AEDs in combination is necessary for effective seizure management. The goal of this work was to characterize the interaction of three AEDs: lacosamide (LCM), carbamazepine (CBZ) and valproate (VPA) at the fixed-ratio of 1:1:1 in the mouse tonic-clonic seizure model. Material and methods. Male albino Swiss mice, after receiving a combination of LCM, CBZ and VPA, were challenged with electric current to evoke tonic hind limb extension (seizure activity). Protection of the mice from tonic-clonic seizures was assessed by isobolographic analysis to determine the type of interaction occurring between these drugs. Results. Type I isobolographic analysis revealed that the combination of LCM, CBZ and VPA produced infra-additive (antagonistic) interaction in the mouse tonic-clonic seizure model. Conclusions. Since the three-drug mixture of LCM, CBZ and VPA exerted an antagonistic interaction in the tonic-clonic seizure test in mice, we would caution physicians against treating epilepsy patients with this unfavorable combination.