2019, Volume 13, Issue 1
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RekordAntagonistic interaction of lacosamide with carbamazepine and valproate in the mouse tonic-clonic seizure model(Państwowa Szkoła Wyższa im. Papieża Jana Pawła II w Białej Podlaskiej, 2019-01-30)Background. It is estimated that approximately 1% of people worldwide suffer from epilepsy. Currently available antiepileptic drugs (AEDs) are able to control epileptic seizures in about 70% of cases. In the remaining patients (30%), the application of two or three AEDs in combination is necessary for effective seizure management. The goal of this work was to characterize the interaction of three AEDs: lacosamide (LCM), carbamazepine (CBZ) and valproate (VPA) at the fixed-ratio of 1:1:1 in the mouse tonic-clonic seizure model. Material and methods. Male albino Swiss mice, after receiving a combination of LCM, CBZ and VPA, were challenged with electric current to evoke tonic hind limb extension (seizure activity). Protection of the mice from tonic-clonic seizures was assessed by isobolographic analysis to determine the type of interaction occurring between these drugs. Results. Type I isobolographic analysis revealed that the combination of LCM, CBZ and VPA produced infra-additive (antagonistic) interaction in the mouse tonic-clonic seizure model. Conclusions. Since the three-drug mixture of LCM, CBZ and VPA exerted an antagonistic interaction in the tonic-clonic seizure test in mice, we would caution physicians against treating epilepsy patients with this unfavorable combination.
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RekordThe use of anti-C6VlsE IgG in the assessment of the effectiveness of Lyme disease treatment - a preliminary report(Państwowa Szkoła Wyższa im. Papieża Jana Pawła II w Białej Podlaskiej, 2019-01-28)Background. The aim of this study was to evaluate the dynamics of changes in IgG anti-C6VlsE concentration in patients treated for Lyme borreliosis in relation to clinical manifestations of the disease. Material and methods. The study group consisted of 20 patients from Ternopil and surrounding areas (Western Ukraine) with clinical symptoms of Lyme borreliosis. IgG anti-C6VlsE was measured three times: before starting the patients on antibiotic therapy, immediately after its completion and 3-4 months after the end of antibiotic therapy. Results. In 40% of the patients the IgG anti-C6VlsE concentration decreased 3-4 months after the treatment, but only in half of them it was associated with elimination of symptoms. 60% of patients did not show any tendency to decrease in IgG anti-C6VlsE concentrations after 3-4 months after the treatment, and 25% of patients in this group had an improvement in health condition. Conclusions. It cannot be excluded that IgG anti-C6VlsE may be important in the serological evaluation of the efficacy of Lyme borreliosis treatment, especially in early stage patients. However, this requires further research, which should be extended to a larger group of patients. It is also important that the assessment of anti-C6VlsE antibody concentration should be performed additionally for a period longer than 4 months from the end of antibiotic therapy.
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RekordCharacteristics as well as past and present possibilities of using microorganisms listed on the CDC list A of biological agents in bioterrorist attacks(Państwowa Szkoła Wyższa im. Papieża Jana Pawła II w Białej Podlaskiej, 2018-10-13)The study aims at characterising four bacterial infectious agents listed on the CDC A list, i.e. Anthrax (Bacillus anthracis), plague (Yersinia pestis), botulism (Clostridium botulinum) and tularemia (Francisella tularensis) as potential tools used in a bioterrorist attack causing diseases. The paper also includes information on their occurrence in Poland and the EU. Despite the real threat of terrorism in the 21st century and large-scale activities aimed at limiting the occurrence of this phenomenon, it should be borne in mind that pathogens listed on the CDC list A, although spotted primarily in animals, can be a real threat to people’s health and life. Among the discussed microorganisms, only Francisella tularensis and Clostridium botulinum cause sporadic diseases in Poland; however, it should be remembered that both Bacillus anthracis, occurring in Europe, and Yersinia pestis, occurring in Asia and Africa, can pose real threats to human health and life not only in natural infections, but when used as a biological weapon.
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RekordTeachers’ expectations regarding the family, the school, the Church and the mass media vis-à-vis the prevention of teen motherhood(Państwowa Szkoła Wyższa im. Papieża Jana Pawła II w Białej Podlaskiej, 2019-02-11)Background. In the recent years, the birth rate among teenage girls has decreased. Although more and more teenagers, especially girls, begin their sexual lives earlier, their knowledge on contraception is usually unsatisfactory and a significant number of adolescents either do not use contraception or use unreliable contraception methods. The lack of sex education at schools leads to teenage students’ lacking knowledge and support in this matter. Material and methods. The tool applied in the research was a previously prepared survey questionnaire entitled Teachers’ and class tutors’ opinions on teen motherhood serving a s the research tool. Results. The interviewees are convinced that in order to prevent pregnancies among adolescent girls, teenagers should be treated individually and provided with reliable knowledge and support. On the other hand, the respondents deem recommendable to warn teenagers of negative consequences that having sex brings and of stigmatisation the sexually active and pregnant girls face. Moreover, the interviewed teachers find it appropriate to promote only sympto-thermal contraception methods. Conclusions. The inconsistency and high restrictiveness in teachers’ opinions affect their involvement in teenagers’ sex education and their support towards pregnant students and underage mothers.
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RekordPerception of health, obesity risk and dietary habits in youth(Państwowa Szkoła Wyższa im. Papieża Jana Pawła II w Białej Podlaskiej, 2018-10-10)Background. The aim of this study was to determine the relationship between eating behaviour, health perception and obesity risk awareness in adolescents. Material and methods. This cross-sectional study was completed with 579 adolescents. Stratified and simple random sampling methods were used in the selection of the high schools, classes and students. The data was collected through the information form, Dutch Eating Behaviour Questionnaire and Perception of Health Scale. Results. The mean score of health perception of the adolescents was 52.34±7.59. There was a positive relationship between total health perception score and emotional eating behaviour score of the adolescents (p=0.003). There was a negative relationship between total health perception score restricted eating behaviour (p=0.029), and external eating behaviour score (p<0.001). The emotional eating behaviour (p=0.007), external eating behaviour (p=0.001) and total eating behaviour score (p<0.001) of the adolescents who believed they had an obesity risk were found to be higher than the adolescents who believed they did not. Conclusions. The adolescents with better health perception are less affected by the environment and are able to restrict their food choices. The adolescents who think that they have an obesity risk consume more food due to their emotional state and external exposure.